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Supplementary data 7. The top five KEGG pathways enriched by each module
The University of AucklandAll significant network modules were enriched for biological pathways. The top five KEGG pathways enrichment results of each of the 14 modules show that the functional modules have distinct biological functions. The top five KEGG pathways results are given in the table.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 8. Centrality values of the central nodes identified from...
The University of AucklandThe top 10% of the proteins ranked by degree, closeness and eigenvector centrality scores were selected. The proteins that are present in common across three groups were defined as central. The central proteins from each module and their corresponding centrality scores are provided in this table.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 9. The central proteins are the targets of FDA approved drugs.
The University of AucklandWe used DGIdb to find the draggability of the central proteins. About 46% (N=80 of 173) of the central proteins across all the modules were targeted by FDA approved drugs. The list of central proteins and their drug targets, and the shared central proteins, their target drugs and the disease informations are provided here.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 10. Functional enrichment of the module containing HLA genes
The University of AucklandThe HLA genes are regulated by at least 10 AiD associated SNPs. Functional module containing HLA genes is highly enriched for immune system related pathways and biological processes. The shared central genes in the module play crucial roles in the biological processes linked to immune system. Here, we provided the details of proteins, GO and KEGG pathways...Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_data_11. A module is enriched for immune function, but not...
The University of AucklandThe module that does not contain HLA genes enriched for immune related biological processes. The shared central genes play crucial role in the biological pathways and ontology terms related to immune system. The details of proteins representing the module, gene ontology biological process and KEGG pathway enrichment results are provided here.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 7. The top five KEGG pathways enriched by each module
The University of AucklandAll significant network modules were enriched for biological pathways. The top five KEGG pathways enrichment results of each of the 14 modules show that the functional modules have distinct biological functions. The top five KEGG pathways results are given in the table.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 12. Functional enrichment results of the largest module...
The University of AucklandThe largest functional module identified from the Ai-PPIN is enriched for diverse biological functions. Mainly, the module consists of proteins involved in cancer suppressor activity (e.g., TP53), signal transduction pathways and various cancer related pathways. The details of the proteins forming the module, GO and KEGG pathways enrichment analysis...Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 7. The top five KEGG pathways enriched by each module
The University of AucklandAll significant network modules were enriched for biological pathways. The top five KEGG pathways enrichment results of each of the 14 modules show that the functional modules have distinct biological functions. The top five KEGG pathways results are given in the table.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 8. Centrality values of the central nodes identified from...
The University of AucklandThe top 10% of the proteins ranked by degree, closeness and eigenvector centrality scores were selected. The proteins that are present in common across three groups were defined as central. The central proteins from each module and their corresponding centrality scores are provided in this table.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 9. The central proteins are the targets of FDA approved drugs
The University of AucklandWe used DGIdb to find the draggability of the central proteins. About 46% (N=80 of 173) of the central proteins across all the modules were targeted by FDA approved drugs. The list of central proteins and their drug targets, and the shared central proteins, their target drugs and the disease informations are provided here.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 10. Functional enrichment of the module containing HLA genes
The University of AucklandThe HLA genes are regulated by at least 10 AiD associated SNPs. Functional module containing HLA genes is highly enriched for immune system related pathways and biological processes. The shared central genes in the module play crucial roles in the biological processes linked to immune system. Here, we provided the details of proteins, GO and KEGG pathways...Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 11. A module is enriched for immune system functions, but...
The University of AucklandThe module that does not contain HLA genes enriched for immune related biological processes. The shared central genes play crucial role in the biological pathways and ontology terms related to immune system. The details of proteins representing the module, gene ontology biological process and KEGG pathway enrichment results are provided here.Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_9
The University of AucklandSupplementary_table_9Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_10
The University of AucklandSupplementary_table_10Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_16
The University of AucklandSupplementary table 16Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_11
The University of AucklandSupplementary_table_11Created 1 April 2021 • Updated 25 April 2024 -
Supplementary data 12. Functional enrichment results of the largest module...
The University of AucklandThe largest functional module identified from the Ai-PPIN is enriched for diverse biological functions. Mainly, the module consists of proteins involved in cancer suppressor activity (e.g., TP53), signal transduction pathways and various cancer related pathways. The details of the proteins forming the module, GO and KEGG pathways enrichment analysis...Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_12
The University of AucklandSupplementary_table_12Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_13
The University of AucklandSupplementary_table_13Created 1 April 2021 • Updated 25 April 2024 -
Supplementary_table_14
The University of AucklandSupplementary_table_14Created 1 April 2021 • Updated 25 April 2024
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